Package: pksensi 1.2.3
pksensi: Global Sensitivity Analysis in Physiologically Based Kinetic Modeling
Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in physiologically based kinetic (PK) models, especially the physiologically based pharmacokinetic/toxicokinetic model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters. The workflow was first mentioned in Hsieh et al., (2018) <doi:10.3389/fphar.2018.00588>, then further refined (Hsieh et al., 2020 <doi:10.1016/j.softx.2020.100609>).
Authors:
pksensi_1.2.3.tar.gz
pksensi_1.2.3.zip(r-4.5)pksensi_1.2.3.zip(r-4.4)pksensi_1.2.3.zip(r-4.3)
pksensi_1.2.3.tgz(r-4.4-any)pksensi_1.2.3.tgz(r-4.3-any)
pksensi_1.2.3.tar.gz(r-4.5-noble)pksensi_1.2.3.tar.gz(r-4.4-noble)
pksensi_1.2.3.tgz(r-4.4-emscripten)pksensi_1.2.3.tgz(r-4.3-emscripten)
pksensi.pdf |pksensi.html✨
pksensi/json (API)
NEWS
| # Install 'pksensi' in R: |
| install.packages('pksensi', repos = c('https://nanhung.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/nanhung/pksensi/issues
- APAP - Pharmacokinetic Dataset of Acetaminophen
gnu-mcsimpharmacokineticssensitivitysensitivity-analysis
Last updated 2 years agofrom:38406a834e. Checks:OK: 7. Indexed: yes.
| Target | Result | Date |
|---|---|---|
| Doc / Vignettes | OK | Sep 10 2024 |
| R-4.5-win | OK | Sep 10 2024 |
| R-4.5-linux | OK | Sep 10 2024 |
| R-4.4-win | OK | Sep 10 2024 |
| R-4.4-mac | OK | Sep 10 2024 |
| R-4.3-win | OK | Sep 10 2024 |
| R-4.3-mac | OK | Sep 10 2024 |
Exports:checkcompile_modelFFPKgenerate_infileheat_checkmcsim_installmcsim_versionpbpk_apap_modelpbtk1cpt_modelpksimrfast99set_rtools40_pathsolve_funsolve_mcsimtell2
Dependencies:clicodetoolscolorspacedata.tabledeSolvedoParallelfansifarverforeachggplot2gluegtableisobanditeratorslabelinglatticelifecyclemagrittrMASSMatrixmgcvmunsellnlmepillarpkgconfigR6RColorBrewerrlangscalestibbleutf8vctrsviridisLitewithr
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| About 'pksensi' package | pksensi-package about-pksensi |
| Pharmacokinetic Dataset of Acetaminophen | APAP |
| Check the Parameter Sensitivity | check heat_check plot.rfast99 print.rfast99 |
| Model Compiler | compile_model |
| Download and install 'GNU MCSim' | mcsim_install mcsim_version set_rtools40_path |
| Example PK Model for Sensitivity Analysis | FFPK models pbpk_apap_model pbtk1cpt_model |
| PK Simulation from Sampling Parameter | pksim |
| Extended Fourier Amplitude Sensitivity Test with Random Phase Shift | rfast99 |
| Solve PK Model Through 'deSolve' Package or Analytical Function | solve_fun |
| Solve PK Model Through 'GNU MCSim' | generate_infile solve_mcsim |
| The Decoupling Simulations | tell2 |
